journals/jamaneurology/article-abstract/2771920 Recommendations of the National Multiple Sclerosis Society. Autologous hematopoietic stem cell transplant in multiple sclerosis. Mesenchymal stem cells for multiple sclerosis: Hype or hope? /journals/laneur/article/PIIS1474-4422(21)00324-0/fulltext fda.gov/consumers/consumer-updates/fda-warns-about-stem-cell-therapies FDA warns about stem cell therapies (2019).fda.gov/vaccines-blood-biologics/consumers-biologics/consumer-alert-regenerative-medicine-products-including-stem-cells-and-exosomes Consumer alert on regenerative medicine products including stem cells and exosomes. Effect of nonmyeloablative hematopoietic stem cell transplantation vs continued disease-modifying therapy on disease progression in patients with relapsing-remitting multiple sclerosis. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. However, the higher efficacy treatments (such as Ocrevus, Alemtuzumab) were not included in that research analysis. Stem cell therapy may be more effective at increasing the time it takes for MS to progress, compared with standard MS treatments. This compared with 9.7% in a placebo group. During a 1-year follow-up, 58.6% of the MSC-IT group and 40.6% of the MSC-IV group exhibited no evidence of disease activity. Doctors treated some intrathecally (IT), which means administering it into the spinal cord. A 2020 clinical trial involved mesenchymal stem cell (MSC) therapy in 48 people with progressive MS.Study authors cited the need for larger, more rigorous trials to compare the benefits of stem cell therapy versus the latest DMTs. A 2021 review article found that aHSCT may benefit people with relapsing and active forms of MS.At 5 years, 67% still had no evidence of disease activity. Two years after therapy, 83% of participants had no evidence of disease activity.
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